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Selected Publications


1. Chao Zhang, Shasha Li, Liyan Ji, Shan Liu, Shuchun Li, Zhongjun Li and Xiangbao Mengsynthesis and antitumor activity of non-camptothecin topoisomerase I inhibitors. Bioorg. Med. Chem. Lett. 2015, 25, 4693-4696.

2. Qing Wang, Xiong Wei, Kaijun Liao, Hui Li, Xiangbao Meng, Zhongjun Li. A convenient preparation of glycosyl sulfoxides and its application to the synthesis of Salidroside epimer. Tetrahedron Lett.2016, 57, 2277- 2279

3. Shuai Meng, Tian Tian, Yun-He Wang, Xiang-Bao Meng and Zhong-Jun Li. Convergent synthesis of oligosaccharides on the gram-scale using cetyl thioglycoside based on a hydrophobically assisted switching phase method. Org. Biomol. Chem.2016, 14, 7722-7730.

4. Xiong Wei, Danlin Liang, Qing Wang, Xiangbao Meng, Zhongjun Li. Total synthesis of mangiferin, homomangiferin,and neomangiferin. Org. Biomol. Chem.2016, 14, 8821-8831.

5. Wenxuan Zhang, Jiming Wang, Xihuan Luo, Xiangbao Meng, Zhongjun Li. An attempt to construct the C/D ring system of parkacine by intramolecular cycloaddition of azomethine ylide and alkyne.  Tetrahedron Lett. 2016, 57, 1981–1984.

6. Yuetao Zhao, Lubai Huang, Qing Li, Zhongjun Li. A mild method for regioselective de-O-methylation of saccharides by Co2(CO)8/Et3SiH/CO system. Tetrahedron 2016, 72, 5699-5706.

7. Jun Yang, Simin Yang, Shanshan Zhou, Dongbo Lu, Liyan Ji, Zhongjun Li, Siwang Yu,  Xiangbao Meng. Synthesis, anti-cancer evaluation of benzenesulfonamide derivatives as potent tubulin-targeting agents. Eur. J. Med. Chem.2016, 122, 488-496.

8. Shan Jiang, Shan Niu,Wang Yao, Zhong-Jun Li, Qing Li. Binding activities of non-β-glucan glycoclusters to dectin-1 and exploration of their binding site. Carbohydr. Res. 2016, 429, 148–154

9. Liu, Bin; Wang, Xin; Ge, Zemei; Li, Runtao.Regioselective Ir(III)-catalyzed C-H alkynylation directed by 7-azaindoles. Organic & Biomolecular Chemistry. 2016, 14(10), 2944-2949.

10. Wang, Shucheng; Huang, Xuhu; Ge, Zemei; Wang, Xin; Li, Runtao. Metal-free C-3 alkylation of imidazopyridines with xanthates and convenient access to alpidem and zolpidem. RSC Advances. 2016, 6(68), 63532-63535.

11. Liu, Bin; Li, Ridong; Zhan, Wei; Wang, Xin; Ge, Zemei; Li, Runtao.  Rh(III)-catalyzed C-H oxidative ortho-olefination of arenes using 7-azaindole as a directing group and utilization in the construction of new tetracyclic heterocycles containing a 7-azaindole skeleton.RSC Advances. 2016, 6(53), 48205-48211.

12. Lu, Yihuan; Zhao, Yuqiong; Wang, Shucheng; Wang, Xin; Ge, Zemei; Li, Runtao. An efficient synthesis of 2-thio-5-amino-substituted benzoquinones via KI catalyzed cascade oxidation/Michael addition/oxidation starting from hydroquinone. RSC Advances. 2016, 6(14), 11378-11381.

13. Wang, Shucheng; Huang, Xuhu; Wang, Qi; Ge, Zemei; Wang, Xin; Li, Runtao. An efficient synthesis of sulfonated quinoline diones by copper catalyzed sulfonylation of activated alkenes with sulfonylhydrazides. RSC Advances. 2016, 6(14), 11754-11757.

14. Li, Ridong; Leng, Penglin; Liu, Bin; Wang, Xin; Ge, Zemei; Li, Runtao. Efficient and regioselective one-pot synthesis of S-vinyl dithiocarbamates from electron-deficient allenes, amines and CS2. Tetrahedron. 2016, 72(37), 5707-5712.

15. Li, Bowen; Zhou, Shuo; Wang, Shucheng; Sun, Xingyi; Ge, Zemei; Li, Runtao. Efficient synthesis of organic sulfonic acid derivatives containing dithiocarbamate side chains. Tetrahedron. 2016, 72(27-28), 3885-3889.

16. Huang Wei; Zhou Quan; Yuan Xia; Ran Fu-Xiang; Ge Ze-Mei; Yang Hua-Yu; Qiang Guang-Liang, Li Run-Tao and Cui Jing-Rong. Proteasome Inhibitor YSY01A Enhances Cisplatin Cytotoxicity in Cisplatin-Resistant Human Ovarian Cancer Cells. Journal of Cancer. 2016, 7(9), 1133-41.

17. Ying-Bo Li, Xu Yan, Ri-Dong Li, Peng Liu, Shao-Qian Sun, Xin Wang, Jing-Rong Cui, De-Min Zhou**, Ze-Mei Ge*, Run-Tao Li. Discovery of novel heteroarylmethylcarbamodithioa-tes as potent anticancer agents: Synthesis, structure-activity relationship analysis and biological evaluation. European Journal of Medicinal Chemistry. 2016112217-230

18. Jianxiong Zhao, Jing Tu, Ningning Fan, Xiangmei Chen, Fengmin Lu, Yu Zhang, Liang Zhang, Chao Tian, Zhili Zhang1, Junyi Liu* & Xiaowei Wang**. Study on 2-arylthio-5-iodo pyrimidine derivatives as novel nonnucleoside inhibitors against hepatitis B virus DNA replication. Future Med. Chem.2016, 1756-8919

19. Shaotong Wu, Qianqian Yin, Liang Zhao, Ningning Fan, Xiaowan Tang, Jianxiong Zhao, Tao Sheng, Ying Guo, Chao Tian, Zhili Zhang, Weisi Xu, Zhenming Liu, Shibo Jiang, Liying Ma,* Junyi Liu* and Xiaowei Wang*. A stereo configuration-activity study of 3-iodo-4-(2-methylcyclohexyloxy)-6-phenethyl pyridin-2(2H)-ones as potency inhibitors of HIV-1 variants. Org. Biomol. Chem. 2016, 14, 1413

20. Xuefeng Sun, Ningning Fan, Weisi Xu, Yixing Sun, Xin Xie, Ying Guo, Liying Ma, Junyi Liu* and Xiaowei Wang*. Design, synthesis and biological evaluation of caffeoyl benzanilides as dual inhibitors of HIV integrase and CCR5. Med. Chem. Commun.2016, 7, 2028

21. Meng Wang, Chao Tian, Xiaowei Wang, Junyi Liu,*, Zhili Zhang.. A convenient one-pot process for the synthesis of 2,4-dihydroxy-6-phenylethylenyl-8- deazapteridine derivatives. Tetrahedron.2016, 72, 22, 2742–2747.

22. Chao Tian, Zhili Zhang, Shouxin Zhou, Mengmeng Yuan, Xiaowei Wang, Junyi Liu. Synthesis, Antifolate and Anticancer Activities of N5-Substituted 8,10-Dideaza tetrahydrofolate Analogues. Chemical Biology & Drug Design, 2016; 87: 444–454

23. Can Cheng, Xianling Ning, Yongming Luo, Chao Tian, Xiaowei Wang, Ying Guo, Junyi Liu, Zhili Zhang*. Synthesis and neuroprotective evaluation of (E)-3,4-dihydroxystyryl p-substituted-phenethyl ketone derivatives against inflammatory and oxidative injury.  Med Chem Res(2016) 25:1678–1685

24. Jing-Xuan Wu, Yi-Hua Hong, Xiao-Gai Yang*. Bis(acetylacetonato) oxidovanadium(IV) and sodium metavanadate inhibit cell proliferation via ROS-induced sustained MAPK/ERK activation but with elevated AKT activity in human pancreatic cancer AsPC-1 cells. J. Biol Inorg Chem. 21:919-9292016

25. Xiao-Gai Yang*, Kui Wang. Focusing on the link between diabetes, Alzheimer's disease and cancer for the discovery of new medicines. Curr Top Med Chem. 16(7):675-676, 2016

26.Wang X, Wang N, Yuan L, Li N, Wang J, Yang X. Exploring tight junction alteration using double fluorescent probe combination of lanthanide complex with gold nanoclusters. Sci Rep. 2016, 6: 32218

27. Niu X, Xiao R, Wang N, Wang Z, Zhang Y, Xia Q, Yang XThe Molecular Mechanisms and Rational Design of Anti-Diabetic Vanadium Compounds. Curr Top Med Chem. 2016, 16/8: 811-822

28. Ji S, Li Z, Song W, Wang Y, Liang W, Li K, Tang S, Wang Q, Qiao X, Zhou D, Yu S*, Ye M*. Bioactive Constituents of Glycyrrhiza uralensis (Licorice): Discovery of the Effective Components of a Traditional Herbal Medicine. J Nat Prod. 2016, 79(2):281-92

29. Zehong Wu, Yongrui Wang, Dong Liu, Peter Proksch, Siwang Yu*, Wenhan Lin*. Antioxidative phenolic compounds from a marine-derived fungus Aspergillus versicolor. Tetrahedron. 2016, 72(1):50-57

30. Que L, He L, Yu C, Yin W, Ma L, Cao B, Yu S*. Activation of Nrf2-ARE signaling mitigates cyclophosphamide-induced myelosuppression. Toxicol Lett. 2016; 262:17-26

31. Guozhou Zhang*, Kun Xiong*, Weiwei Ma, Wei Xu, Huihui Zeng. Initiate Tumors with Single Cell Spheres Formed in Serum-Containing Medium. Journal of Cancer. 2015; 6(9): 901-912

32. Zheng X, Zhang Y, Zhang L, Xu W, Ma W, Sun R and Zeng H. Synergistic inhibition of sunitinib and ethaselen against human colorectal cancer cells proliferation. Biomed Pharmacother. 2016, 83:212-220

33. Dong C, Zhang L, Sun R, Liu J, Yin H, Li X, Zheng X and Zeng H. Role of thioredoxin reductase 1 in dysplastic transformation of human breast epithelial cells triggered by chronic oxidative stress. Scientific Reports. 2016, 6: 36860

34. Suofu Ye, Xiaoqing Zheng, Tianjiao Hu, Huihui Zeng. Synthesis, SAR and Biological Evaluation of a novel series of 1-(2-chloroethyl)-1-nitroso-3-(2-(3-oxobenzoelenazol-2(3H)-yl) ethyl) urea: Organoselenium compounds for cancer therapy. Cellular and molecular biology. 2016, 62 (7): 6-14

35. Shuang Guo, Chen-Qi Zhu, Ya-Ya Gao Yang, Bai-Ling Qiu, Di Wu, Qi-Hui Liang, Nan-Yin Han *. Effects of Comprehensive Function of Factors on Retention Behavior of Microparticles in Gravitational Field-Flow Fractionation. Journal of Chromatography B. 1031:1-7, 2016

36. Dan Wang, Jijun Fu, Yujie Shi, Dong Peng, Lan Yuan, Bing He, Wenbing Dai, Hua Zhang, XueqingWang, Jie Tian, Qiang Zhang. The modulation of tumor vessel permeability by thalidomide and its impacts on different types of targeted drug delivery systems in a sarcoma mouse model. Journal of Controlled Release. 238 :186-196, 2016

37. Dan WANG, Xiao-Wei LI, Xuan WANG*, Huan-Ran TAN, Yan JIA, Li YANG, Xiao-Mei LI, Ming-Ying SHANG, Feng XU, Xing-Xin YANG, Yukihiro SHOYAMA, Shao-Qing CAI. Alpha-actinin-4 is a possible target protein for aristolochic acid I in human kidney cells in vitro. The American Journal of Chinese Medicine. 2016, 44(2): 1-14.

38. Yu J, Ma CM, Wang X, Shang MY, Hattori M, Xu F, Jing Y, Dong SW, Xu YQ, Zhang CY, Cai SQ. Analysis of aristolochic acids, aristololactams and their analogues using liquid chromatography tandem mass spectrometry. Chinese Journal of Natural Medicines.2016, 14(8):626-640

39. Chao Tian, Zhili Zhang, Shouxin Zhou, Mengmeng Yuan, Xiaowei Wang and Junyi Liu. Synthesis, Antifolate and Anticancer Activities of N5-Substituted 8,10-Dideazatetra-hydrofolate Analogues. Chemical Biology & Drug Design. 2016; 87: 444–454.

40. Qun Zhang, Yang Liu, Bao-Di Gou, Lei Zheng, Yu-Xi Gao and Tian-Lan Zhang. Quantitative chemical relations at pseudoequilibrium in amorphous calcium phosphate formation. RSC Adv., 2016, 6, 102710–102723


1. Zhang, Yu; Liu, Bin; Wu, Xingyu; Li, Ridong; Ning, Xianling; Liu, Yu; Liu, Zhenming; Ge, Zemei; Li, Runtao;*Yin, Yuxin*. New pyridin-3-ylmethyl carbamodithioic esters activate pyruvate kinase M2 and potential anticancer lead compounds, Bioor. Med. Chem, 2015, 23(15), 4815-4823.

2. Liu, Bin; Huang, Xuhu; Wang, Xin; Ge, Zemei*; Li, Runtao*.Palladium catalyzed amide-oxazoline directed C-H acetoxylation of arenes. Org. Chem. Front.2015, 2(7), 797-800.

3. Wang, Jie; Tan, Hailiang; Sun, Qi; Ge, Zemei; Wang, Xin; Wang, Yinye*; Li, Runtao*.Design, synthesis and biological evaluation of pyridazino[3,4,5-de]-quinazolin-3(2H)-one as a new class of PARP-1 inhibitors. Bioor. Med. Chem Letters, 2015, 25(11),2340-2344.

4. Bai, Zhushuang; Ji, Ling; Ge, Zemei; Wang, Xin*; Li, Runtao*. Asymmetric Michael addition reactions of nitroalkanes to 2-furanones catalyzed by bifunctional thiourea catalysts. Org. Biomol. Chem. 2015, 13(19), 5363-5366.

5. Huang, Xuhu; Wang, Shucheng; Li, Bowen; Wang, Xin; Ge, Zemei*; Li, Runtao*. Iodine-triphenylphosphine mediated sulfenylation of imidazoheter-ocycles with sodium sulfonates,RSC Advances, 2015, 5(29), 22654-22657.

6. Wang, Shucheng; Huang, Xuhu; Li, Bowen; Ge, Zemei; Wang, Xin; Li, Runtao*. A metal-free synthesis of oxindoles by a radical addition-cyclization onto N-arylacrylamides with xanthates.Tetrahedron, 2015, 71(12), 1869-1875.

7. Wang, Huiling; Li, Ridong; Li, Li; Ge, Zemei; Zhou, Rouli*; Li, Runtao*. LRD-22, a novel dual dithiocarbamatic acid ester, inhibits Aurora-A kinase and induces apoptosis and cell cycle arrest in HepG2 cells. Biochem. Biophys. Res. Commun.2015, 458(1), 201-207.

8. Li, Ri-Dong; Wang, Hui-Ling; Li, Ying-Bo; Wang, Zhong-Qing; Wang, Xin; Wang, Yi-Tao; Ge, Ze-Mei*; Li, Run-Tao*.Discovery and optimization of novel dual dithiocarbamates as potent anticancer agents. Eur. J. Med. Chem.2015, 93, 381-391.

9. Luo, Laichun; Meng, Lanlan; Peng, Yangqiu; Xing, Yongning; Sun, Qi*; Ge, Zemei; Li, Runtao*. ZnCl2-Promoted One-Pot Three-Component Synthesis of MultisubstitutedThiazolo[4,5-b]pyridines and Thieno[2,3- b:4,5-b']dipyridines.Eur. J. Org. Chem. 2015, 2015(3), 631-637.

10. Zhao, Shuo; Wu, You; Sun, Qi*; Cheng, Tie-Ming; Li, Run-Tao*. Triphenylphos-phine-N- Bromosuccinimide Mediated Chemoselective Cyclodehydration of Diols. Synthesis, 2015, 47(8), 1154-1162.

11. Shucheng Wang, Xuhu Huang, Yanzhao Wen, Zemei Ge, Xin Wang, Runtao Li*. Cascade synthesis of spirooxindole d-lactone derivatives through N-aryl hydroxymethylacrylamides with xanthates. Tetrahedron, 2015, 71, 8117-8122,

12. Zhang Chao, Bo Zhong, Simin Yang, Liankun Pan, Siwang Yu, Zhongjun Li, Shuchun Li, Bin Su, Xiangbao Meng. Synthesis and Biological Evaluation of Thiabendazole Derivatives as Anti-angiogenesis and vascular disrupting Agents. Bioorg. Med. Chem. 2015, 23, 3774-3780.

13. ShuaiMeng, Tian Tian, Dong Han, Lin-Na Wang, Shao-Geng Tang, Xiang-BaoMeng, Zhong-Jun Li, Efficient Assembly of oligomannosides using the hydrophobically assisted switching phase method. Org. Biomol. Chem.2015, 13, 6711-6722.

14. Yunfeng Li, Meng Yao, Zhongjun Li, XiangbaoMeng. Stereoselective and regioselective one-pot synthesis of polyhydroxy bicyclic diazenes and hydrazones from methyl 6-deoxy-6-iodohexosides. Tetrahedron, 2015, 71, 5385-5390.

15. Xiaochao Xue, Wei Li, Zhaojun Yin, Xiangbao Meng, Zhongjun Li, Concise and direct construction of cis-pyrano[4,3-b]pyran-5-one skeleton from glucal derivatives: synthesis of ent-4-deoxy-2,3-di-epi-dinemasone BC. Tetrahedron Lett. 2015, 56, 5228-5230.

16. Pengzhan Qian, Wang Yao, Lubai Huang, Xiangbao Meng, Zhongjun Li. A mild and efficient method for the selective cleavage of primary p-methoxybenzyl protecting group of saccharides by Co2(CO)8-Me2PhSiH-CO system. Tetrahedron Lett. 2015, 56, 5238-5241.

17. Shan Jiang, Shan Niu, Zhi-Hui Zhao, Zhong-Jun Li, Qing Li. Synthesis of a series of novel heteroglycoclusters and homoglycoclusters and the study of their anti-adhesion activities. Carbohydr. Res. 2015, 414, 39-45.

18. Chao Zhang, Shasha Li, Liyan Ji, Shan Liu, Zhongjun Li, Shuchun Li, and Xiangbao Meng. Synthesis and antitumor activity of non-camptothecin topoisomerase I inhibitors. Bioorg. Med. Chem. Lett.,2015, 25, 4693-4696.

19. Yuanyuan Cao, Yu Zhang, Shaotong Wu, Quanzhi Yang, Xuefeng Sun, Jianxiong Zhao, Fen Pei, Ying Guo, Chao Tian, Zhili Zhang, Haining Wang, Liying Ma, Junyi Liu,* and Xiaowei Wang*. Synthesis and biological evaluation of pyridinone analogues as novel potent HIV-1 NNRTIs. Bioorg. Med. Chem.23 (2015) 149–159

20. Yu Zhang, Xuefeng Sun,Ningning Fan,Jianxiong Zhao,Jing Tu,Xiangmei Chen,Junyi Liu* and Xiaowei Wang*. 5-Iodo-2-arylalkylthio-6-aryl pyrimidin-4(3H)-ones as non-nucleoside anti-HBV agents. Med. Chem. Commun., 2015, 6, 1438–1443

21. Tong-Bo Zhang, Yuan-Yuan Cao, Shao-Tong Wu, Yu Zhang, Ying Guo, Jian-Xiong Zhao, Xue-Feng Sun, Quan-Zhi Yang, Zhi-Li Zhang, Chao Tian, Jun-Yi Liu*and Xiao-Wei Wang.* An approach to synthesis of pyrimido[b]azepines via Ruthenium-catalyzed ring-closing metathesis. Synthesis 2015, 47, 3292–3300

22. Weisi Xu, Jianxiong Zhao, Jianping Sun, Qianqian Yin, Yan Wang, Yang Jiao, Junyi Liu, ShiboJiang, Yiming Shao, Xiaowei Wang,* and Liying Ma.* The HEPT analogue, 1-((benzyloxy) methyl)-6-(3,5-dimethylbenzyl)-5-iodopyrimidine-2,4(1H,3H)-dione(WPR-6), is active against a broad spectrum of HIV-1 strains of different subtypes with drug-resistance. Antimicrob. Agents Chemother. 2015, 59:84882-4888

23. Xianling Ning, Mengmeng Yuan, Ying Guo, Chao Tian, Xiaowei Wang, Zhili Zhang & Junyi Liu*. Neuroprotective effects of (E)-3,4-diacetoxystyryl sulfone and sulfoxide derivatives in vitro models of Parkinson's disease. J Enzyme Inhib Med Chem, 2015, 1475-6366

24. Ying-Yuan Lu, Xin Wang, Xiao-WeiWang, Jun-Yi Liu, Pu Li, Hong Ren, Ya-Qing Lou, Chuang Lu and Guo-Liang Zhang. Development and validation of a high performance liquid chromatography method for determination of 6-benzyl-1-benzyloxymethyl-5-iodouracil (W-1), a novel non-nucleoside reverse transcriptase inhibitor and its application to a pharmacokinetic study in rats. Biomed. Chromatogr.2015DOI 10.1002/bmc.3457

25. Shaotong Wu, Qianqian Yin, Liang Zhao, Ningning Fan, Xiaowan Tang, Jianxiong Zhao, Tao Sheng, Ying Guo, Chao Tian, Zhili Zhang, Weisi Xu, Zhenming Liu, Shibo Jiang, Liying Ma,* Junyi Liu* and Xiaowei Wang*, A stereo configuration-activity study of 3-iodo-4-(2-methylcyclohexyloxy)-6-phenethylpyridin-2 (2H)-ones as potency inhibitors of HIV-1 variants. Org. Biomol. Chem.2015, DOI: 10.1039/c5ob02154e

26. Chao Tian, Zhili Zhang, Shouxin Zhou, Mengmeng Yuan, Xiaowei Wang, Junyi Liu, Synthesis, Antifolate and Anticancer Activities of N5-Substituted 8,10-Dideazatetrahydrofolate Analogues. Chemical Biology & Drug Design,2015, doi: 10.1111/cbdd.12681

27. Xiao-Gai Yang*, Kui Wang, Focusing on the link between diabetes, Alzheimer's disease and cancer for the discovery of new medicines. Curr Top Med Chem.2016, 16(7):675-676

28. Min Feng, Yun-Zhou Fan, Xiao-Jie Ma, Jin-Xia Li,Xiao-Gai Yang*, The gadolinium-based contrast agent Omniscan promotes in vitro fibroblast survival through in situ precipitation, Metallomics, 2015, 7:1103-1110

29. Zhang, Q.; Jiang, Y.; Gou, B.-D.; Huang, J.; Gao, Y.-X.; Zhao, J.-T.; Zheng, L.; Zhao, Y.-D.; Zhang, T.-L.; Wang, K., In situ detection of calcium phosphate clusters in solution and wet amorphous phase by synchrotron X-ray absorption near-edge spectroscopy at calcium K-edge. Cryst. Growth Des. 2015, 15(5), 2204-2210.

30. Wang N, Wang Z, Niu X, Yang X, Synthesis, characterization and anti-diabetic therapeutic potential of novel aminophenol-derivatized nitrilotriacetic acid vanadyl complexes, J. Inorg. Biochem., 2015, 152: 104–113

31. Wang X, Lei R, Huang H, Wang N, Yuan L, Xiao R, Bai L, Li X, Li L, Yang, XThe permeability and transport mechanism of graphene quantum dots (GQDs) across the biological barrier, Nanoscale, 2015, 7: 2034-2041

32. Peng Xu, Min Li, Yanping Βai, Wei Lu, Xiaomei Ling*, Weidong Li*The effects of piracetam on heroin-induced CPP and neuronal apoptosis in rats, Drug and Alcohol Dependence, 2015. 150:141-146

33. Zhongjie Li, Yiran Zhao, Weiwei Lin, Xiaobo Hu, MinYe*, Xiaodan Zhang, Xiaomei Ling*Rapid screening and identification of active ingredients in licoriceextract interacting with V3 loop region of HIV-1 gp120 using ACE andCE-MSJournal of Pharmaceutical and  Biomedical Analysis, Journal of Pharmaceutical and Biomedical Analysis. 111 (2015), 28–35

34. Jing Li, Wensi Lin, Weiwei Lin, Peng Xu, Jianmei Zhang, Haisong Yang, Xiaomei Ling, Metabolic profiling study on potential toxicity and immunotoxicity-biomarker discovery in rats treated with cyclophosphamide using HPLC-ESI-IT-TOF-MS, Biomedical Chromatography, 2015, 29(5):768–776