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张志丽

副教授、硕士生导师

张志丽:博士,副教授

电话:(010)-8280 5203

E-mail:lilybmu@bjmu.edu.cn

通讯地址:北京市海淀区学院路38号北京大学医学部药学院507  邮编:100191

    2004年北京大学药学院药物化学专业博士毕业,同年在药学院365bet提前结束投注任教至今。2010-2011年公派到法国奥尔良大学有机和分析化学系从事研究工作。主要从事单碳单位转移酶抑制剂类抗肿瘤药物的研究,以钴氨素依赖的蛋氨酸合成酶作为抗肿瘤作用的新靶点,发现了具有良好肿瘤细胞抑制作用的先导化合物。近年以第一作者和责任作者在国外SCI和国内核心杂志发表科研论文10余篇。获“一种四氢吡啶并[3,2-d]嘧啶类化合物及制备抗肿瘤药物的用途”中国专利授权一项。

获奖情况

   2007年度获得北京大学医学部优秀教师,2009年获得北京大学药学院第九届青年教师讲课比赛一等奖,2011年获得北京大学绿叶生物医药杰出青年学者奖。

研究方向

  单碳单位转移酶抑制剂类抗肿瘤药物的研究

目前研究课题:

  1.基于蛋氨酸合成酶新靶点的抗肿瘤药物研究

  2.化药1.1类抗肿瘤药-蛋氨酸合成酶抑制剂ZZL-33合成工艺与初步成药性研究

代表性科研论文及专利:

1. Xianling Ning, Ying Guo, Xiaoyan Ma, Renzong Zhu, Chao Tian, Xiaowei Wang, Zhizhong Ma, Zhili Zhang,* and Junyi Liu,* Synthesis and neuroprotective effect  of E-3,4-dihydroxy styryl aralkyl ketones derivatives against oxidative stress and inflammation. Bioorg. Med. Chem. Lett. 2013, 23, 3700.

2. Zhili Zhang, Chao Tian, Shouxin Zhou, Wei Wang, Ying Guo, Jie Xia, Zhenming Liu, Biao Wang, Xiaowei Wang, Junyi Liu, et al, Mechanism-based design, synthesis and biological studies of N5-substituted tetrahydrofolate analogues as inhibitors of cobalamin-dependent methionine synthase and potential anticancer agents. Euro. J. Med. Chem. 2012, 58, 228.

3. Shouxin Zhou, Chao Tian, Chao Li, Ying Guo, Xiaowei Wang, Junyi Liu, Zhili Zhang*. Novel synthesis of 8-deaza-5,6,7,8-tetrahydroaminopterin analogues via an aziridine intermediate. Molecules, 2012, 17, 5604.

4. Zhili Zhang, Jun Wu, Fuxiang Ran, Ying Guo, Ran Tian, Shouxin Zhou, et al, Novel 8-deaza-5,6,7,8-tetrahydro aminopterin derivatives as dihydrofolate inhibitor: design, synthesis and antifolate activity. Eur. J. Med. Chem. 2009, 44, 764.

5. Zhili Zhang, Zhijian Cheng, Xiaoyan Ma, et al, Facile alternative synthesis of 1-alkyl-5-alkylamino-6-phenethyluracils. Synth. Commu. 2009, 39, 2310.

6. Zhili Zhang, Jie Liu, Weidong Liu, Xiaowei Wang, et al, Synthesis of 2-amino-4-hydroxyl-6-hydroxymethyl-5,6,7,8-tetrahydropyrido[3,2-d] pyrimidine from 2-amino-4-hydroxyl-6-methylpyrimidine J. Heterocyclic Chem., 2009, 46, 1151.

7. Jie Liu, Weidong Liu, Zhili Zhang*, Zhijian Cheng, Xiaoyan Ma, Xiaowei Wang, Junyi Liu, Synthesis of 1-amino-6, 7-dihydro-7-(hydroxymethyl)-4-nitro-pyrrolo(1, 2-f) pyrimidin-3-(5H)-one from 2-amino-6-methylpyrimidin-3-one, Synth. Commu. 2009, 39, 2244.

8. Jie Liu, Weidong Liu, Zhili Zhang*, Zhijian Chen, et al, Synthesis of 1-amino-6, 7-dihydro-7-(hydroxymethyl)-4-nitro-pyrrolo(1,2-f)pyrimidin-3-(5H)-one from 2-amino-6 -methylpyrimidin-3-one. Synth. Commun. 2009, 39, 2244.

9. Cai Tang, Zhili Zhang, Bo Xu, Min Li, Junyi Liu, Jingrong Cui.* Two newly synthesized 5-methyltetrahydrofolate-like compounds inhibit methionine synthase activity accompanied by cell cycle arrest in G1/S phase and apoptosis in vitro. Anti-cancer Drugs. 2008, 19, 697.

10. Zhili Zhang, Shouxin Zhou, Xiaowei Wang, Hongtao Wang, Yanli Chen, Junyi Liu*, Tetrabutylammon hydroxide: an efficient catalyst of N-alkylation of pyrimidines and purines. Chem. Res. Chinese U. 2006, 22(4), 451.

11. Zhili Zhang, Peng Han, Xiaoyan Ma, Jie Liu, Xiaowei Wang, Junyi Liu*. The benzoylation of 6-methyluracil and 5-nitro-6-methyluracil. Chin. Chem. Lett. 2005, 16(3), 287.

12. 专利申请四项

1) 名称:四氢叶酸类似物的合成新方法。申请号201110260992.8,发明人:刘俊义,周受辛,张志丽。

2) E-3,4-二羟苯乙烯基亚砜类化合物的制备方法及其作为神经保护药物的应用。申请号2013011800137090,发明人:刘俊义,宁显玲,张志丽,郭莹,王孝伟,田超。

3) E-3,4-二羟苯乙烯基酮类化合物的制备方法及其作为神经保护药物的应用。申请号2013011800137350,发明人:刘俊义,宁显玲,张志丽,郭莹,王孝伟,田超。

4) E-3,4-二羟苯乙烯基磺酰胺和磺酸酯类化合物的制备方法及其作为神经保护剂的应用。申请号2013011800137170,发明人:刘俊义,宁显玲,陈柱陀,张志丽,郭莹,王孝伟,田超

13. 专利授权一项

名称:一种四氢吡啶并[3,2-d]嘧啶类化合物及制备抗肿瘤药物的用途。专利号:ZL 2005 1 0117745.7。发明人:张志丽,刘俊义。